5 Revolutionary Back Pain Treatments to Try in 2025
5 Revolutionary Back Pain Treatments to Try in 2025
Wearable Smart Gadgets for Real-Time Pose Modification
The Function of Wearable Smart Instruments in Revolutionizing Pain In The Back Treatments
As we step into the futuristic landscape of health care in 2025, neck and back pain stays a relentless ailment affecting millions worldwide. Visit https://sites.google.com/view/back-pain-treatment-melbourne/home https://sites.google.com/view/back-pain-treatment-melbourne/home to book your next session for pain relief.. Nevertheless, the advent of wearable wise tools for real-time posture correction sticks out as a sign of innovation, guaranteeing an innovative technique to reducing this olden issue. This essay delves into the transformative possibility of such devices in the realm of pain in the back therapies.
Gone are the days when neck and back pain patients relied only on periodic brows through to a physiotherapist or chiropractor. With the intro of wearable clever gadgets tailored for position adjustment, people are now encouraged to take charge of their back health and wellness in real time. These sophisticated devices are ingeniously designed to be light-weight, inconspicuous, and perfectly integrated right into the day-to-days live of individuals.
At the heart of these devices lies the sophisticated blend of sensors and artificial intelligence. Sensing units constantly keep an eye on the users stance throughout the day, detecting slouches, misalignments, and any inconsistencies from a healthy spine curvature. When inadequate posture is determined, the gadget sends out mild vibrations or acoustic hints, triggering the individual to adjust their placement. This instantaneous responses loop not only aids in dealing with position in the minute yet likewise educates the muscle mass and mind to maintain an ideal pose in time, efficiently minimizing stress and stress and anxiety on the back.
In addition, the real-time data gathered by these gadgets gives invaluable understandings into postural routines, aiding individuals to recognize patterns and tasks that add to their neck and back pain. By syncing with mobile phones or various other wise modern technologies, the tool can use individualized guidance, exercises, and even relaxation methods, all tailored to the users particular demands and development.
The implications of this modern technology are extensive for preventative treatment. By resolving poor stance before it ends up being a chronic concern, these wearable devices have the prospective to dramatically minimize the incidence of neck and back pain, which in turn can reduce the need for even more invasive treatments like surgical procedure or long-lasting medicine.
Furthermore, the assimilation of such gadgets right into telehealth solutions improves the scope of remote medical diagnosis and treatment. Patients can share their stance data with doctor, enabling more exact evaluations and customized treatment plans without the requirement for frequent in-person check outs.
Finally, as we want to 2025 and past, wearable wise tools for real-time stance improvement stand out as an advanced treatment for neck and back pain. By merging the benefit of wearable innovation with the accuracy of real-time data, these devices supply an aggressive approach to back
Genetics Therapy for Long-Term Pain Relief
Gene Treatment for Long-Term Pain Relief: A Glimpse into the Future of Pain In The Back Management
The year is 2025, and the landscape of back pain treatment is experiencing a transformative period, identified by advancement and cutting-edge innovation. Amongst one of the most revolutionary therapies that have actually arised, gene treatment stands out as a beacon of wish for those who struggle with chronic neck and back pain. This unique technique is not only pioneering in its technique however also assures lasting relief, which has been a far-off dream for many people.
Genetics therapy for back pain operates on a principle that is as classy as it is intricate-- it involves the alteration of a people genes to treat or protect against disease. In the context of back pain, this treatment targets the hereditary elements that contribute to the inflammation, nerve damages, and tissue degeneration that are frequently at the origin of relentless discomfort.
The procedure of gene treatment starts with the identification of specific genes that influence pain experience or inflammatory actions. Scientists have actually made significant strides in this field, identifying genetic pens that can be adjusted to lower pain without the requirement for repeated medicine programs. As soon as these genes are determined, a safe infection or one more vector is genetically crafted to carry healthy and balanced or tweaked genes right into the human cells.
Individuals undertaking gene therapy for back pain receive an injection directly right into the afflicted location of the spine. This local method makes certain that the restorative genes get to the intended site, supplying a targeted treatment that lessens systemic negative effects. The presented genes then function to either reduce the overactive pain signals or advertise the healing of broken tissues.
What collections gene treatment apart from standard pain management strategies is its possibility for durable alleviation. As opposed to masking signs with pain relievers or going through intrusive surgical treatments, patients can eagerly anticipate a future where their bodys own genetic make-up is used to deal with pain from within. As the modified genetics integrate into the patients DNA, the healing results can sustain for several years, dramatically improving the quality of life for those afflicted with chronic back pain.
Furthermore, gene treatment is individualized. Each treatment can be customized to the individuals hereditary profile, raising the performance and reducing the likelihood of adverse reactions. This bespoke approach to pain management advertises a brand-new era of accuracy medication, where therapies are designed to fit each clients special genetic blueprint.
The promise of genetics treatment for long-term pain alleviation is not without its obstacles. The roadway to extensive clinical application has actually been led with extensive screening, ethical factors to consider, and governing approvals. Nevertheless, the strides made
Virtual Truth as a Tool for Chronic Pain In The Back Management
Digital Fact as a Tool for Chronic Back Pain Monitoring: A Glance into the Future of Recovery
As we venture much deeper right into the 21st century, the world of pain monitoring is undertaking a transformation, one that combines the borders between technology and human feeling. Online Truth (VR), as soon as an invention of sci-fi, has now come to be a beacon of hope for those suffering from persistent pain in the back. In the advanced landscape of 2025, VR isn't merely a tool for home entertainment however an advanced therapeutic modality that is redefining the way we approach neck and back pain treatment.
The concept of making use of virtual reality for persistent pain in the back monitoring originates from its capacity to immerse individuals in an alternative reality, one where the restrictions and pains of their physical bodies can be transcended. This immersive experience is greater than just a disturbance; it's a form of cognitive behavior modification that educates clients just how to better recognize and handle their pain.
In a normal virtual reality neck and back pain management session, individuals don a VR headset and are transferred to peaceful settings, be it a sunlit forest glade or a serene coastline. These settings are not arbitrary; they are meticulously crafted to advertise relaxation and mindfulness. The patient participates in assisted exercises and tasks designed to advertise movement, versatility, and strength, all within the convenience of a digital globe that reduces the fear of pain that frequently accompanies physical treatment.
The scientific research behind this innovative strategy lies in the brains capacity to be deceived by digital stimulations. As people navigate their online surroundings, their brains are coaxed into creating pain-inhibiting feedbacks. This sensation, called "" VR analgesia,"" has actually shown appealing cause reducing the perception of pain. Furthermore, VRs interactive nature motivates active participation, which is important in the recovery process.
The psychological advantages of virtual reality treatment are similarly remarkable. Persistent back pain can frequently lead to depression, anxiety, and a sense of isolation. Through virtual reality, patients get in touch with a community of fellow victims and doctor, fostering a feeling of support and friendship that is critical for psychological wellness. They discover dealing strategies and mindfulness methods that not just help take care of pain but also enhance their general quality of life.
As we welcome these pioneering treatments in 2025, we see a change from a reliance on pharmaceuticals to a much more alternative strategy to pain monitoring. VR treatment is not a standalone cure however a corresponding treatment that boosts traditional treatments such as physical therapy, medication, and interventional procedures. It represents a tailored method,
Customized 3D-Printed Spine Implants and Sustains
In the evolving landscape of clinical technology, the realm of orthopedic care has been particularly transformed by the advent of customized 3D-printed back implants and supports. As we look towards 2025, this cutting-edge technique stands as a sign of hope for those struggling with chronic neck and back pain, advertising a new age of individualized and effective treatment choices.
Customized 3D-printed spine implants and supports are an item of the marital relationship in between advanced imaging techniques and sophisticated 3D printing technology. By utilizing in-depth scans of a people one-of-a-kind back composition, doctor can currently design implants and sustains that are tailored to the individuals specific requirements. This degree of personalization makes certain that the implants fit flawlessly, minimizing the threat of rejection and difficulties that can develop from ill-fitting, mass-produced choices.
The ramifications for pain in the back patients are extensive. For numerous, standard back surgical procedure can be a complicated possibility, with lengthy recovery times and the potential for just partial relief from pain. Nevertheless, with the accuracy provided by 3D printing, cosmetic surgeons can target the afflicted area with a much higher degree of accuracy, resulting in even more successful end results. This can lead to considerably minimized pain, improved movement, and a quicker return to day-to-day tasks.
Moreover, the products made use of in 3D printing can be picked for their compatibility with the body and their sturdiness. This indicates that the implants can be developed not just to give architectural assistance but likewise to assist in the bodys natural recovery processes. Some 3D-printed materials can even promote bone growth, causing a stronger, more integrated repair gradually.
For those with degenerative problems or intricate spinal concerns, customized 3D-printed implants stand for a quantum leap forward. Clients that may have encountered a life time of pain and limited movement now have the possible to delight in a more active and comfortable life. The degree of personalization in the implants can deal with the source of pain with unmatched accuracy, lowering the need for pain medications and more treatments.
In 2025, as this innovation ends up being a lot more widespread and easily accessible, we can expect a significant change in just how pain in the back is treated. Custom-made 3D-printed spinal implants and assistances will likely end up being the requirement of treatment, providing hope and recovery to the numerous people afflicted by pain in the back. This is truly an innovative development; one that guarantees to redefine the limits of spinal treatment and restore the quality of life to plenty of people all over the world.
There is no cure for AS. Treatments may include medication, physical therapy, and surgery. Medication therapy focuses on relieving the pain and other symptoms of AS, as well as stopping disease progression by counteracting long-term inflammatory processes. Commonly used medications include NSAIDs, TNF inhibitors, IL-17 antagonists, and DMARDs. Glucocorticoid injections are often used for acute and localized flare-ups.[9]
About 0.1% to 0.8% of the population are affected, with onset typically occurring in young adults.[2][4] While men and women are equally affected with AS, women are more likely to experience inflammation rather than fusion.[10]
The signs and symptoms of ankylosing spondylitis often appear gradually, with peak onset between 20 and 30 years of age.[11] Initial symptoms are usually a chronic dull pain in the lower back or gluteal region combined with stiffness of the lower back.[12] Individuals often experience pain and stiffness that awakens them in the early morning hours.[11]
As the disease progresses, loss of spinal mobility and chest expansion, with a limitation of anterior flexion, lateral flexion, and extension of the lumbar spine are seen. Systemic features are common with weight loss, fever, or fatigue often present.[11] Pain is often severe at rest but may improve with physical activity. Inflammation and pain may recur to varying degrees regardless of rest and movement.
AS can occur in any part of the spine or the entire spine, often with pain localized to either buttock or the back of the thigh from the sacroiliac joint. Arthritis in the hips and shoulders may also occur. When the condition presents before the age of 18, AS is more likely to cause pain and swelling of large lower limb joints, such as the knees.[13] In prepubescent cases, pain and swelling may also manifest in the ankles and feet where heel pain and enthesopathy commonly develop.[13] Less common occurrences include ectasia of the sacral nerve root sheaths.[14]
Single nucleotide polymorphism (SNP) A/G variant rs10440635[18] is close to the PTGER4 gene on human chromosome 5 has been associated with an increased number of cases of AS in a population recruited from the United Kingdom, Australia, and Canada. The PTGER4 gene codes for the prostaglandin EP4 receptor, one of four receptors for prostaglandin E2. Activation of EP4 promotes bone remodeling and deposition (see prostaglandin EP4 receptor § Bone) and EP4 is highly expressed at vertebral column sites involved in AS. These findings suggest that excessive EP4 activation contributes to pathological bone remodeling and deposition in AS and that the A/G variant rs10440635a of PTGER4 predisposes individuals to this disease, possibly by influencing EP4's production or expression pattern.[19][20]
The association of AS with HLA-B27 suggests the condition involves CD8 T cells, which interact with HLA-B.[21] This interaction is not proven to involve a self-antigen, and at least in the related reactive arthritis, which follows infections, the antigens involved are likely to be derived from intracellular microorganisms.[7] There is, however, a possibility that CD4+ T lymphocytes are involved in an aberrant way, since HLA-B27 appears to have a number of unusual properties, including possibly an ability to interact with T cell receptors in association with CD4 (usually CD8+ cytotoxic T cell with HLAB antigen as it is a MHC class 1 antigen).
"Bamboo spine" develops when the outer fibers of the fibrous ring (anulus fibrosus disci intervertebralis) of the intervertebral discs ossify, which results in the formation of marginal syndesmophytes between adjoining vertebrae.
34-year-old male with AS. Inflammatory lesions of the anterior chest wall are shown (curved arrows). Inflammatory changes are seen in the lower thoracic spine and L1 (arrows).
Ankylosing spondylitis is a member of the more broadly defined disease axial spondyloarthritis.[22][23] Axial spondyloarthritis can be divided into two categories: radiographic axial spondyloarthritis (which is a synonym for ankylosing spondylitis) and non-radiographic axial spondyloarthritis (which include less severe forms and early stages of ankylosing spondylitis).[22]
While AS can be diagnosed through the description of radiological changes in the sacroiliac joints and spine, there are currently no direct tests (blood or imaging) to unambiguously diagnose early forms of ankylosing spondylitis (non-radiographic axial spondyloarthritis). Diagnosis of non-radiologic axial spondyloarthritis is therefore more difficult and is based on the presence of several typical disease features.[22][24]
These diagnostic criteria include:
Inflammatory back pain:
Chronic, inflammatory back pain is defined when at least four out of five of the following parameters are present: (1) Age of onset below 40 years old, (2) insidious onset, (3) improvement with exercise, (4) no improvement with rest, and (5) pain at night (with improvement upon getting up). Pain often subsides as the day progresses with movement being of importance to alleviate the joint stiffness.
Past history of inflammation in the joints, heels, or tendon-bone attachments
Family history for axial spondyloarthritis or other associated rheumatic/autoimmune conditions
The earliest changes demonstrable by plain X-ray shows erosions and sclerosis in sacroiliac joints. Progression of the erosions leads to widening of the joint space and bony sclerosis. X-ray spine can reveal squaring of vertebrae with bony spur formation called syndesmophyte. This causes the bamboo spine appearance. A drawback of X-ray diagnosis is the signs and symptoms of AS have usually been established as long as 7–10 years prior to X-ray-evident changes occurring on a plain film X-ray, which means a delay of as long as 10 years before adequate therapies can be introduced.[25]
Options for earlier diagnosis are tomography and MRI of the sacroiliac joints, but the reliability of these tests is still unclear.
Lateral X-ray of the mid back in ankylosing spondylitis
Lateral X-ray of the neck in ankylosing spondylitis
X-ray showing bamboo spine in a person with ankylosing spondylitis
CT scan showing bamboo spine in ankylosing spondylitis
T1-weighted MRI with fat suppression after administration of gadolinium contrast showing sacroiliitis in a person with ankylosing spondylitis
During acute inflammatory periods, people with AS may show an increase in the blood concentration of CRP and an increase in the ESR, but there are many with AS whose CRP and ESR rates do not increase, so normal CRP and ESR results do not always correspond with the amount of inflammation that is actually present. In other words, some people with AS have normal levels of CRP and ESR, despite experiencing a significant amount of inflammation in their bodies.[26]
Variations of the HLA-B gene increase the risk of developing ankylosing spondylitis, although it is not a diagnostic test. Those with the HLA-B27 variant are at a higher risk than the general population of developing the disorder. HLA-B27, demonstrated in a blood test, can occasionally help with diagnosis, but in itself is not diagnostic of AS in a person with back pain. Over 85% of people that have been diagnosed with AS are HLA-B27 positive, although this ratio varies from population to population (about 50% of African Americans with AS possess HLA-B27 in contrast to the figure of 80% among those with AS who are of Mediterranean descent).[27]
The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), developed in Bath (UK), is an index designed to detect the inflammatory burden of active disease. The BASDAI can help to establish a diagnosis of AS in the presence of other factors such as HLA-B27 positivity, persistent buttock pain which resolves with exercise, and X-ray or MRI-evident involvement of the sacroiliac joints.[28] It can be easily calculated and accurately assesses the need for additional therapy; a person with AS with a score of four out of a possible 10 points while on adequate NSAID therapy is usually considered a good candidate for biologic therapy.
The Bath Ankylosing Spondylitis Functional Index (BASFI) is a functional index which can accurately assess functional impairment due to the disease, as well as improvements following therapy.[29] The BASFI is not usually used as a diagnostic tool, but rather as a tool to establish a current baseline and subsequent response to therapy.
Juvenile ankylosing spondylitis (JAS) is a rare form of the disease which differs from the more common adult form.[13]Enthesophathy and arthritis of large joints of the lower extremities is more common than the characteristic early-morning back pain seen in adult AS.[13] Ankylosing tarsitis of the ankle is a common feature, as is the more classical findings of seronegative ANA and RF as well as presence of the HLA-B27 allele.[13] Primary engagement of the appendicular joints may explain delayed diagnosis; however, other common symptoms of AS such as uveitis, diarrhea, pulmonary disease and heart valve disease may lead suspicion away from other juvenile spondyloarthropathies.[13]
Medications for AS may be broadly considered either "disease-modifying" or "non-disease-modifying". Disease-modifying medications for ankylosing spondylitis aim to slow disease progression and include drugs like tumor necrosis factor (TNF) inhibitors. Non-disease-modifying medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), primarily address symptoms like pain and inflammation but do not alter the course of the disease.[32]
Unless otherwise contraindicated, all people with AS are recommended to take non-steroidal anti-inflammatory drugs (NSAIDs). The dose, frequency, and specific drug may depend on the individual and the symptoms they experience. NSAIDs, such as ibuprofen and naproxen, are used to alleviate pain, reduce inflammation, and improve joint stiffness associated with AS. These medications work by inhibiting the activity of cyclooxygenase (COX) enzymes, which are involved in the production of inflammatory prostaglandins. By reducing the levels of prostaglandins, NSAIDs help mitigate the inflammatory response and relieve symptoms in individuals with ankylosing spondylitis.[9][33]
Tumor necrosis factor inhibitors (TNFi) are a class of biologic drugs used in the treatment of ankylosing spondylitis. TNFi drugs, such as etanercept, infliximab, adalimumab, certolizumab, and golimumab, target the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). TNF-alpha plays a key role in the inflammatory process in ankylosing spondylitis. By blocking TNF-alpha, TNFi drugs help reduce inflammation, pain, and stiffness associated with AS, and may also slow down the progression of spinal damage.[9][34]
Non-TNFi "biologic" drugs used in the treatment of ankylosing spondylitis include drugs that target different pathways involved in the inflammatory process. Two of the most important drugs in this class target IL-17, an important part of the inflammatory system: secukinumab and ixekizumab. They are often considered in cases where TNFi drugs are not effective or cause too many side effects. Additionally, they may sometimes be used as an adjunct to a TNFi when symptoms persist, but improve, while the patient is on the TNFi. The choice of a specific non-TNFi biologic depends on various factors, including the patient's medical history, preferences, and the recommendations of the healthcare provider.[9]
Ustekinumab has frequently been used as a second-line therapy for AS, but it has recently been scrutinized for a lack of efficacy, and is no longer recommended.[35][9]
Biosimilar drugs are biological products that are highly similar to an already approved biologic drug, with few or no clinically meaningful differences in terms of safety, purity, and potency. These drugs are developed to be equivalent to the reference biologic, often at a lower cost, providing alternative treatment options. In the context of ankylosing spondylitis, biosimilars are typically used as alternatives to the original biologic drugs. Biosimilars for ankylosing spondylitis may include versions of tumor necrosis factor inhibitors or other biologics commonly used in the treatment of the condition. When possible, physicians are recommended to use the original drugs over the biosimilar versions. Even biosimilars with perfect replication of the quality, composition, and other properties of the original drug are susceptible to nocebo effects.[9][36]
Conventional synthetic antirheumatic drugs (csARDs) are a class of disease-modifying medications. Unlike biologics or targeted synthetic drugs, which act on specific pathways in the immune system, csARDs have a broader effect on the immune system and are often considered traditional or conventional treatments. The most common drugs in this class are methotrexate and sulfasalazine. These medications are only used when others fail, or when certain specific conditions are met, and are often discontinued if a patient's symptoms become manageable with just a TNFi or other medication. Conventional DMARDs such as leflunomide are also considered to be part of this class.[9]
Concerns exist about a possible lack of efficacy of some drugs in this class.[37]
Glucocorticoids, such as prednisone or methylprednisolone, are sometimes used in the treatment of ankylosing spondylitis to manage acute flares and provide short-term relief from inflammation and symptoms. They are powerful anti-inflammatory medications that can help reduce pain, swelling, and stiffness associated with AS. However, glucocorticoids are generally not recommended for long-term use. They are more commonly used as localized injections when someone with AS has a temporary pain flare in a particular joint or area.[9]
In severe cases of AS, surgery can be an option in the form of joint replacements, particularly in the knees and hips. Surgical correction is also possible for those with severe flexion deformities (severe downward curvature) of the spine, particularly in the neck, although this procedure is considered very risky. In addition, AS can have some manifestations that make anesthesia more complex. Changes in the upper airway can lead to difficulties in intubating the airway, spinal and epidural anesthesia may be difficult owing to calcification of ligaments, and a small number of people have aortic insufficiency. The stiffness of the thoracic ribs results in ventilation being mainly diaphragm-driven, so there may also be a decrease in pulmonary function.
Though physical therapy remedies have been scarcely documented, some therapeutic exercises are used to help manage lower back, neck, knee, and shoulder pain. There is moderate quality evidence that therapeutic exercise programs help reduce pain and improve function.[38] Therapeutic exercises include:[39][40]
Research by Alan Ebringer at King's College in London, beginning in the 1980s, implicates overgrowth of the bacterium Klebsiella pneumoniae in the symptoms of ankylosing spondylitis. The body produces antibodies that attack Klebsiella pneumoniae. Enzymes made by the bacterium resemble human proteins, including three types of collagen (I, III, IV) and the HLA-B27 complex of glycoproteins. The antibodies therefore attack these human proteins, producing the symptoms of ankylosing spondylitis. Ebringer and others recommend low-starch or no-starch diets.[43]
Fracture of the T5 and C7 vertebra due to trauma in a person with ankylosing spondylitis as seen on a CT scan
Prognosis is related to disease severity.[11] AS can range from mild to progressively debilitating and from medically controlled to refractory. Some cases may have times of active inflammation followed by times of remission resulting in minimal disability while others never have times of remission and have acute inflammation and pain, leading to significant disability.[11] As the disease progresses, it can cause the vertebrae and the lumbosacral joint to ossify, resulting in the fusion of the spine.[44] This places the spine in a vulnerable state because it becomes one bone, which causes it to lose its range of motion as well as putting it at risk for spinal fractures. This not only limits mobility but reduces the affected person's quality of life. Complete fusion of the spine can lead to a reduced range of motion and increased pain, as well as total joint destruction which could necessitate a joint replacement.[45]
Osteoporosis is common in ankylosing spondylitis, both from chronic systemic inflammation and decreased mobility resulting from AS. Over a long-term period, osteopenia or osteoporosis of the AP spine may occur, causing eventual compression fractures and a back "hump".[46] Hyperkyphosis from ankylosing spondylitis can also lead to impairment in mobility and balance, as well as impaired peripheral vision, which increases the risk of falls which can cause fracture of already-fragile vertebrae.[46] Typical signs of progressed AS are the visible formation of syndesmophytes on X-rays and abnormal bone outgrowths similar to osteophytes affecting the spine. In compression fractures of the vertebrae, paresthesia is a complication due to the inflammation of the tissue surrounding nerves.
Mortality is increased in people with AS and circulatory disease is the most frequent cause of death.[49] People with AS have an increased risk of 60% for cerebrovascular mortality, and an overall increased risk of 50% for vascular mortality.[50] About one third of those with ankylosing spondylitis have severe disease, which reduces life expectancy.[51]
As increased mortality in ankylosing spondylitis is related to disease severity, factors negatively affecting outcomes include:[49][52]
The hunched position that often results from complete spinal fusion can have an effect on a person's gait. Increased spinal kyphosis will lead to a forward and downward shift in center of mass (COM). This shift in COM has been shown to be compensated by increased knee flexion and ankle dorsiflexion. The gait of someone with ankylosing spondylitis often has a cautious pattern because they have decreased ability to absorb shock, and they cannot see the horizon.[54]
Between 0.1% and 0.8% of people are affected.[4] The disease is most common in Northern European countries, and seen least in people of Afro-Caribbean descent.[11] Although the ratio of male to female disease is reportedly 3:1,[11] many rheumatologists believe the number of women with AS is underdiagnosed, as most women tend to experience milder cases of the disease. The majority of people with AS, including 95 per cent of people of European descent with the disease, express the HLA-B27 antigen[55] and high levels of immunoglobulin A (IgA) in the blood.[56] In 2007, a team of researchers discovered two genes that may contribute to the cause of AS: ARTS-1 and IL23R.[57] Together with HLA-B27, these two genes account for roughly 70 percent of the overall number of cases of the disease.
Drawing from 1857 of Leonard Trask who had a severe case of AS
Ankylosing spondylitis was distinguished from rheumatoid arthritis by Galen as early as the 2nd century AD.[58] Skeletal evidence of the disease (ossification of joints and entheses primarily of the axial skeleton, known as "bamboo spine") was thought to be found in the skeletal remains of a 5000-year-old Egyptian mummy with evidence of bamboo spine.[59][60] However, a subsequent report found that this was not the case.[61]
The anatomist and surgeon Realdo Colombo described what could have been the disease in 1559,[62] and the first account of pathologic changes to a skeleton possibly associated with AS was published in 1691 by Bernard Connor.[63] In 1818, Benjamin Brodie became the first physician to document a person believed to have active AS who also had accompanying iritis.[64]
In 1858, David Tucker published a small booklet which clearly described the case of Leonard Trask, who had severe spinal deformity subsequent to AS.[65] In 1833, Trask fell from a horse, exacerbating the condition and resulting in severe deformity. Tucker reported:
It was not until he [Trask] had exercised for some time that he could perform any labor ... [H]is neck and back have continued to curve drawing his head downward on his breast.
The account of Trask became the first documented case of AS in the United States, owing to its indisputable description of inflammatory disease characteristics of AS and the hallmark of deforming injury in AS.
In the late nineteenth century, the neurophysiologistVladimir Bekhterev of Russia in 1893,[66]Adolf Strümpell of Germany in 1897,[67] and Pierre Marie of France in 1898[68] were the first to give adequate descriptions which permitted an accurate diagnosis of AS prior to severe spinal deformity. For this reason, AS is also known as Bekhterev disease, Bechterew's disease or Marie–Strümpell disease.
The word is from Greekankylos meaning crooked, curved or rounded, spondylos meaning vertebra, and -itis meaning inflammation.[2]
^Cantini F, Nannini C, Cassarà E, Kaloudi O, Niccoli L (November 2015). "Uveitis in Spondyloarthritis: An Overview". The Journal of Rheumatology. Supplement. 93: 27–9. doi:10.3899/jrheum.150630. PMID26523051. S2CID24715271.
^Deodhar A, Reveille JD, van den Bosch F, Braun J, Burgos-Vargas R, Caplan L, et al. (October 2014). "The concept of axial spondyloarthritis: joint statement of the spondyloarthritis research and treatment network and the Assessment of SpondyloArthritis international Society in response to the US Food and Drug Administration's comments and concerns". Arthritis & Rheumatology. 66 (10): 2649–56. doi:10.1002/art.38776. PMID25154344. S2CID38228595.
^ abPoddubnyy D, van Tubergen A, Landewé R, Sieper J, van der Heijde D (August 2015). "Development of an ASAS-endorsed recommendation for the early referral of patients with a suspicion of axial spondyloarthritis". Annals of the Rheumatic Diseases. 74 (8): 1483–7. doi:10.1136/annrheumdis-2014-207151. PMID25990288. S2CID42585224.
^Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (December 1994). "A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index". The Journal of Rheumatology. 21 (12): 2286–91. PMID7699630.
^Calin A, Garrett S, Whitelock H, Kennedy LG, O'Hea J, Mallorie P, Jenkinson T (December 1994). "A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index". The Journal of Rheumatology. 21 (12): 2281–5. PMID7699629.
^Thomas E, Silman AJ, Papageorgiou AC, Macfarlane GJ, Croft PR (February 1998). "Association between measures of spinal mobility and low back pain. An analysis of new attenders in primary care". Spine. 23 (3): 343–7. doi:10.1097/00007632-199802010-00011. PMID9507623. S2CID41982757.
^Akkoc, Nurullah; van der Linden, Sjef; Khan, Muhammad Asim (June 2006). "Ankylosing spondylitis and symptom-modifying vs disease-modifying therapy". Best Practice & Research. Clinical Rheumatology. 20 (3): 539–557. doi:10.1016/j.berh.2006.03.003. ISSN1521-6942. PMID16777581.
^Zhao Q, Dong C, Liu Z, Li M, Wang J, Yin Y, Wang R (August 2020). "The effectiveness of aquatic physical therapy intervention on disease activity and function of ankylosing spondylitis patients: a meta-analysis". Psychology, Health & Medicine. 25 (7): 832–843. doi:10.1080/13548506.2019.1659984. PMID31475583. S2CID201714910.
^Romanowski MW, Straburzyńska-Lupa A (19 March 2020). "Is the whole-body cryotherapy a beneficial supplement to exercise therapy for patients with ankylosing spondylitis?". Journal of Back and Musculoskeletal Rehabilitation. 33 (2): 185–192. doi:10.3233/BMR-170978. PMID31594196. S2CID203984335.
^ abAlpert JS (2006). The AHA Clinical Cardiac Consult. Lippincott Williams & Wilkins. ISBN978-0-7817-6490-2.
^Ahn NU, Ahn UM, Nallamshetty L, Springer BD, Buchowski JM, Funches L, et al. (October 2001). "Cauda equina syndrome in ankylosing spondylitis (the CES-AS syndrome): meta-analysis of outcomes after medical and surgical treatments". Journal of Spinal Disorders. 14 (5): 427–33. doi:10.1097/00002517-200110000-00009. PMID11586143.
^ abBakland G, Gran JT, Nossent JC (November 2011). "Increased mortality in ankylosing spondylitis is related to disease activity". Annals of the Rheumatic Diseases. 70 (11): 1921–5. doi:10.1136/ard.2011.151191. PMID21784726. S2CID39397817.
^Radford EP, Doll R, Smith PG (September 1977). "Mortality among patients with ankylosing spondylitis not given X-ray therapy". The New England Journal of Medicine. 297 (11): 572–6. doi:10.1056/NEJM197709152971103. PMID887115.
^Brionez TF, Reveille JD (July 2008). "The contribution of genes outside the major histocompatibility complex to susceptibility to ankylosing spondylitis". Current Opinion in Rheumatology. 20 (4): 384–91. doi:10.1097/BOR.0b013e32830460fe. PMID18525349. S2CID205485848.
^Leden I (1994). "Did Bechterew describe the disease which is named after him? A question raised due to the centennial of his primary report". Scandinavian Journal of Rheumatology. 23 (1): 42–5. doi:10.3109/03009749409102134. PMID8108667.
Systematic reviews of controlled clinical studies of treatments used by chiropractors have found no evidence that chiropractic manipulation is effective, with the possible exception of treatment for back pain.[7] A 2011 critical evaluation of 45 systematic reviews concluded that the data included in the study "fail[ed] to demonstrate convincingly that spinal manipulation is an effective intervention for any condition."[9] Spinal manipulation may be cost-effective for sub-acute or chronic low back pain, but the results for acute low back pain were insufficient.[10] No compelling evidence exists to indicate that maintenance chiropractic care adequately prevents symptoms or diseases.[11]
There is not sufficient data to establish the safety of chiropractic manipulations.[12] It is frequently associated with mild to moderate adverse effects, with serious or fatal complications in rare cases.[13] There is controversy regarding the degree of risk of vertebral artery dissection, which can lead to stroke and death, from cervical manipulation.[14] Several deaths have been associated with this technique[13] and it has been suggested that the relationship is causative,[15][16] a claim which is disputed by many chiropractors.[16]
Chiropractic is well established in the United States, Canada, and Australia.[17] It overlaps with other manual-therapy professions such as osteopathy and physical therapy.[18] Most who seek chiropractic care do so for low back pain.[19] Back and neck pain are considered the specialties of chiropractic, but many chiropractors treat ailments other than musculoskeletal issues.[7] Chiropractic has two main groups: "straights", now the minority, emphasize vitalism, "Innate Intelligence", and consider vertebral subluxations to be the cause of all disease; and "mixers", the majority, are more open to mainstream views and conventional medical techniques, such as exercise, massage, and ice therapy.[20]
D. D. Palmer founded chiropractic in the 1890s,[21] claiming that he had received it from "the other world".[22] Palmer maintained that the tenets of chiropractic were passed along to him by a doctor who had died 50 years previously.[23] His son B. J. Palmer helped to expand chiropractic in the early 20th century.[21] Throughout its history, chiropractic has been controversial.[24][25] Its foundation is at odds with evidence-based medicine, and is underpinned by pseudoscientific ideas such as vertebral subluxation and Innate Intelligence.[26] Despite the overwhelming evidence that vaccination is an effective public health intervention, there are significant disagreements among chiropractors over the subject,[27] which has led to negative impacts on both public vaccination and mainstream acceptance of chiropractic.[28] The American Medical Association called chiropractic an "unscientific cult" in 1966[29] and boycotted it until losing an antitrust case in 1987.[8] Chiropractic has had a strong political base and sustained demand for services. In the last decades of the twentieth century, it gained more legitimacy and greater acceptance among conventional physicians and health plans in the United States.[8] During the COVID-19 pandemic, chiropractic professional associations advised chiropractors to adhere to CDC, WHO, and local health department guidance.[30][31] Despite these recommendations, a small but vocal and influential number of chiropractors spread vaccine misinformation.[32]
Chiropractic's origins lie in the folk medicine of bonesetting,[7] and as it evolved it incorporated vitalism, spiritual inspiration and rationalism.[33] Its early philosophy was based on deduction from irrefutable doctrine, which helped distinguish chiropractic from medicine, provided it with legal and political defenses against claims of practicing medicine without a license, and allowed chiropractors to establish themselves as an autonomous profession.[33] This "straight" philosophy, taught to generations of chiropractors, rejects the inferential reasoning of the scientific method,[33] and relies on deductions from vitalistic first principles rather than on the materialism of science.[34] However, most practitioners tend to incorporate scientific research into chiropractic,[33] and most practitioners are "mixers" who attempt to combine the materialistic reductionism of science with the metaphysics of their predecessors and with the holistic paradigm of wellness.[34] A 2008 commentary proposed that chiropractic actively divorce itself from the straight philosophy as part of a campaign to eliminate untestable dogma and engage in critical thinking and evidence-based research.[35]
Although a wide diversity of ideas exist among chiropractors,[33] they share the belief that the spine and health are related in a fundamental way, and that this relationship is mediated through the nervous system.[36] Some chiropractors claim spinal manipulation can have an effect on a variety of ailments such as irritable bowel syndrome and asthma.[37]
Chiropractic philosophy includes the following perspectives:[34]
Holism assumes that health is affected by everything in an individual's environment; some sources also include a spiritual or existential dimension.[38] In contrast, reductionism in chiropractic reduces causes and cures of health problems to a single factor, vertebral subluxation.[35]Homeostasis emphasizes the body's inherent self-healing abilities. Chiropractic's early notion of innate intelligence can be thought of as a metaphor for homeostasis.[33]
A large number of chiropractors fear that if they do not separate themselves from the traditional vitalistic concept of innate intelligence, chiropractic will continue to be seen as a fringe profession.[20] A variant of chiropractic called naprapathy originated in Chicago in the early twentieth century.[39][40] It holds that manual manipulation of soft tissue can reduce "interference" in the body and thus improve health.[40]
Not to be confused with subluxation, the mainstream concept of a medical condition.
In science-based medicine, the term "subluxation" refers to an incomplete or partial dislocation of a joint, from the Latin luxare for "dislocate".[41][42] Whereas medical doctors use the term exclusively to refer to physical dislocations, Chiropractic founder D. D. Palmer imbued the word subluxation with a metaphysical and philosophical meaning drawn from pseudoscientific traditions such as Vitalism.[43]
Palmer claimed that vertebral subluxations interfered with the body's function and its inborn ability to heal itself.[44] D. D. Palmer repudiated his earlier theory that vertebral subluxations caused pinched nerves in the intervertebral spaces in favor of subluxations causing altered nerve vibration, either too tense or too slack, affecting the tone (health) of the end organ.[43] He qualified this by noting that knowledge of innate intelligence was not essential to the competent practice of chiropractic.[43] This concept was later expanded upon by his son, B. J. Palmer, and was instrumental in providing the legal basis of differentiating chiropractic from conventional medicine.
Vertebral subluxation, a core concept of traditional chiropractic, remains unsubstantiated and largely untested, and a debate about whether to keep it in the chiropractic paradigm has been ongoing for decades.[45] In general, critics of traditional subluxation-based chiropractic (including chiropractors) are skeptical of its clinical value, dogmatic beliefs and metaphysical approach. While straight chiropractic still retains the traditional vitalistic construct espoused by the founders, evidence-based chiropractic suggests that a mechanistic view will allow chiropractic care to become integrated into the wider health care community.[45] This is still a continuing source of debate within the chiropractic profession as well, with some schools of chiropractic still teaching the traditional/straight subluxation-based chiropractic, while others have moved towards an evidence-based chiropractic that rejects metaphysical foundings and limits itself to primarily neuromusculoskeletal conditions.[46][47]
In 2005, the chiropractic subluxation was defined by the World Health Organization as "a lesion or dysfunction in a joint or motion segment in which alignment, movement integrity and/or physiological function are altered, although contact between joint surfaces remains intact.[48] It is essentially a functional entity, which may influence biomechanical and neural integrity."[48] This differs from the medical definition of subluxation as a significant structural displacement, which can be seen with static imaging techniques such as X-rays.[48] The use of X-ray imaging in the case of vertebral subluxation exposes patients to harmful ionizing radiation for no evidentially supported reason.[49][50] The 2008 book Trick or Treatment states "X-rays can reveal neither the subluxations nor the innate intelligence associated with chiropractic philosophy, because they do not exist."[51]Attorney David Chapman-Smith, Secretary-General of the World Federation of Chiropractic, has stated that "Medical critics have asked how there can be a subluxation if it cannot be seen on X-ray. The answer is that the chiropractic subluxation is essentially a functional entity, not structural, and is therefore no more visible on static X-ray than a limp or headache or any other functional problem."[52] The General Chiropractic Council, the statutory regulatory body for chiropractors in the United Kingdom, states that the chiropractic vertebral subluxation complex "is not supported by any clinical research evidence that would allow claims to be made that it is the cause of disease."[53]
As of 2014, the US National Board of Chiropractic Examiners states "The specific focus of chiropractic practice is known as the chiropractic subluxation or joint dysfunction. A subluxation is a health concern that manifests in the skeletal joints, and, through complex anatomical and physiological relationships, affects the nervous system and may lead to reduced function, disability or illness."[54][26]
Straights (Vitalists) versus Mixers (Materialists)
1914 advertisement for a Straight Chiropractic as opposed to a Mixer Chiropractic
By 1914,[55] chiropractors had begun to divide into two groups: "Straights", adherents of the Palmers' supernatural vitalist beliefs, and "Mixers" who sought to integrate Chiropractic into science-based mainstream medicine.[56]: 172
Originally, Straight chiropractors adhered to pseudoscientific Vitalist ideas set forth by D.D. and B.J. Palmer, and even modern "straights" often retain metaphysical definitions and vitalistic qualities.[57] Straight chiropractors believed that vertebral subluxation leads to interference with an "innate intelligence" exerted via the human nervous system and is a primary underlying risk factor for many diseases.[57] Straights view the medical diagnosis of patient complaints, which they consider to be the "secondary effects" of subluxations, to be unnecessary for chiropractic treatment.[57] Thus, straight chiropractors are concerned primarily with the detection and correction of vertebral subluxation via adjustment and do not "mix" other types of therapies into their practice style.[57] Their philosophy and explanations were metaphysical in nature, and they preferred to use traditional chiropractic lexicon terminology such as "perform spinal analysis", "detect subluxation", "correct with adjustment".[20] They preferred to remain separate and distinct from mainstream health care.[20] Modernly, "Straights" are a minority among Chiropractors, though "they have been able to transform their status as purists and heirs of the lineage into influence dramatically out of proportion to their numbers."[20]
Mixers, who make up the majority of chiropractors, "mix" chiropractic with diagnostic and treatment approaches from mainstream medical and osteopathic practices.[20] Unlike straight chiropractors, mixers believe subluxation is just one of many causes of disease, and mixers are open to mainstream medicine.[20] Many mixers incorporate mainstream medical diagnostics and employ conventional medical treatments including techniques of physical therapy such as exercise, stretching, massage, ice packs, electrical muscle stimulation, therapeutic ultrasound, and moist heat.[20] But some mixers also use techniques from pseudoscientific alternative medicine, including unnecessary nutritional supplements, acupuncture, homeopathy, herbal remedies, and biofeedback.[20] Author Holly Folk writes that "Few Mixer chiropractors use the term anymore. Today, one is more likely to hear this side described as 'holistic,' 'wellness-oriented,' or 'integrative' practitioners."[56]: 114 Folk argues that "osteopathy underwent a 'Straight-Mixer' debate between traditional vitalists and a faction that embraced the new medical science".: 172
Although mixers are the majority group, many of them retain belief in vertebral subluxation as shown in a 2003 survey of 1,100 North American chiropractors, which found that 88 percent wanted to retain the term "vertebral subluxation complex", and that when asked to estimate the percent of disorders of internal organs that subluxation significantly contributes to, the mean response was 62 percent.[58] A 2008 survey of 6,000 American chiropractors demonstrated that most chiropractors seem to believe that a subluxation-based clinical approach may be of limited utility for addressing visceral disorders, and greatly favored non-subluxation-based clinical approaches for such conditions.[59] The same survey showed that most chiropractors generally believed that the majority of their clinical approach for addressing musculoskeletal/biomechanical disorders such as back pain was based on subluxation.[59] Chiropractors often offer conventional therapies such as physical therapy and lifestyle counseling, and it may for the lay person be difficult to distinguish the unscientific from the scientific.[60]
While some chiropractors limit their practice to short-term treatment of musculoskeletal conditions, many falsely claim to be able treat a myriad of other conditions.[61][62] Some dissuade patients from seeking medical care, others have pretended to be qualified to act as a family doctor.[61]
Quackwatch, an alternative medicine watchdog, cautions against seeing chiropractors who:[61][63]
Treat young children
Discourage immunization
Pretend to be a family doctor
Take full spine X-rays
Promote unproven dietary supplements
Are antagonistic to scientific medicine
Claim to treat non-musculoskeletal problems
Writing for the Skeptical Inquirer, one physician cautioned against seeing even chiropractors who solely claim to treat musculoskeletal conditions:
I think Spinal Manipulation Therapy (SMT) is a reasonable option for patients to try ... But I could not in good conscience refer a patient to a chiropractor... When chiropractic is effective, what is effective is not 'chiropractic': it is SMT. SMT is also offered by physical therapists, DOs, and others. These are science-based providers ... If I thought a patient might benefit from manipulation, I would rather refer him or her to a science-based provider.[61]
Chiropractors emphasize the conservative management of the neuromusculoskeletal system without the use of evidence-based medicines or surgery,[48] with special emphasis on the spine.[2] Back and neck pain are the specialties of chiropractic but many chiropractors treat ailments other than musculoskeletal issues.[7] There is a range of opinions among chiropractors: some believed that treatment should be confined to the spine, or back and neck pain; others disagreed.[64] For example, while one 2009 survey of American chiropractors had found that 73% classified themselves as "back pain/musculoskeletal specialists", the label "back and neck pain specialists" was regarded by 47% of them as a least desirable description in a 2005 international survey.[64] It has been proposed that chiropractors specialize in nonsurgical spine care, instead of attempting to also treat other problems,[35][65] but the more expansive view of chiropractic is still widespread.[66]
Mainstream health care and governmental organizations such as the World Health Organization consider chiropractic to be complementary and alternative medicine (CAM);[1] and a 2008 study reported that 31% of surveyed chiropractors categorized chiropractic as CAM, 27% as integrated medicine, and 12% as mainstream medicine.[67] Many chiropractors believe they are primary care providers,[7][8] including US[68] and UK chiropractors,[69] but the length, breadth, and depth of chiropractic clinical training do not support the requirements to be considered primary care providers,[2] so their role on primary care is limited and disputed.[2][8]
Chiropractic overlaps with several other forms of manual therapy, including massage therapy, osteopathy, physical therapy, and sports medicine.[18][70] In a 2010 article on the history of manipulative therapy, the author opined that "physical therapy emerged and grew alongside osteopathy, chiropractic, and the evolving “scientific” medical profession. However, over the next 100 years, physical therapy, osteopathy, and chiropractic were destined to travel very different paths. In its country of origin, osteopathy would coalesce with the medical profession. Chiropractic would remain autonomous from, and highly competitive with, medicine. Physical therapy, whose roots lay in working alongside and cooperating with medical physicians, continues to do so."[71][needs update]. Osteopathy outside the US remains primarily a manual medical system;[72] physical therapists work alongside and cooperate with mainstream medicine, and osteopathic medicine in the U.S. has merged with the medical profession.[71] Practitioners may distinguish these competing approaches through claims that, compared to other therapists, chiropractors heavily emphasize spinal manipulation, tend to use firmer manipulative techniques, and promote maintenance care; that osteopaths use a wider variety of treatment procedures; and that physical therapists emphasize machinery and exercise.[18]
Chiropractic diagnosis may involve a range of methods including skeletal imaging, observational and tactile assessments, and orthopedic and neurological evaluation.[48] A chiropractor may also refer a patient to an appropriate specialist, or co-manage with another health care provider.[65] Common patient management involves spinal manipulation (SM) and other manual therapies to the joints and soft tissues, rehabilitative exercises, health promotion, electrical modalities, complementary procedures, and lifestyle advice.[4]
A chiropractic adjustment of a horse
Chiropractors are not normally licensed to write medical prescriptions or perform major surgery in the United States[73] (although New Mexico has become the first US state to allow "advanced practice" trained chiropractors to prescribe certain medications[74][75]). In the US, their scope of practice varies by state, based on inconsistent views of chiropractic care: some states, such as Iowa, broadly allow treatment of "human ailments"; some, such as Delaware, use vague concepts such as "transition of nerve energy" to define scope of practice; others, such as New Jersey, specify a severely narrowed scope.[76] US states also differ over whether chiropractors may conduct laboratory tests or diagnostic procedures, dispense dietary supplements, or use other therapies such as homeopathy and acupuncture; in Oregon they can become certified to perform minor surgery and to deliver children via natural childbirth.[73] A 2003 survey of North American chiropractors found that a slight majority favored allowing them to write prescriptions for over-the-counter drugs.[58] A 2010 survey found that 72% of Swiss chiropractors considered their ability to prescribe nonprescription medication as an advantage for chiropractic treatment.[77]
A related field, veterinary chiropractic, applies manual therapies to animals and is recognized in many US states,[78] but is not recognized by the American Chiropractic Association as being chiropractic.[79] It remains controversial within certain segments of the veterinary and chiropractic professions.[80]
No single profession "owns" spinal manipulation and there is little consensus as to which profession should administer SM, raising concerns by chiropractors that other medical physicians could "steal" SM procedures from chiropractors.[81] A focus on evidence-based SM research has also raised concerns that the resulting practice guidelines could limit the scope of chiropractic practice to treating backs and necks.[81] Two US states (Washington and Arkansas) prohibit physical therapists from performing SM,[82] some states allow them to do it only if they have completed advanced training in SM, and some states allow only chiropractors to perform SM, or only chiropractors and physicians. Bills to further prohibit non-chiropractors from performing SM are regularly introduced into state legislatures and are opposed by physical therapist organizations.[83]
A chiropractor performs an adjustment on a patient.
Spinal manipulation, which chiropractors call "spinal adjustment" or "chiropractic adjustment", is the most common treatment used in chiropractic care.[84] Spinal manipulation is a passive manual maneuver during which a three-joint complex is taken past the normal range of movement, but not so far as to dislocate or damage the joint.[85] Its defining factor is a dynamic thrust, which is a sudden force that causes an audible release and attempts to increase a joint's range of motion.[85] High-velocity, low-amplitude spinal manipulation (HVLA-SM) thrusts have physiological effects that signal neural discharge from paraspinal muscle tissues, depending on duration and amplitude of the thrust are factors of the degree in paraspinal muscle spindles activation.[86] Clinical skill in employing HVLA-SM thrusts depends on the ability of the practitioner to handle the duration and magnitude of the load.[86] More generally, spinal manipulative therapy (SMT) describes techniques where the hands are used to manipulate, massage, mobilize, adjust, stimulate, apply traction to, or otherwise influence the spine and related tissues.[85]
There are several schools of chiropractic adjustive techniques, although most chiropractors mix techniques from several schools. The following adjustive procedures were received by more than 10% of patients of licensed US chiropractors in a 2003 survey:[84]Diversified technique (full-spine manipulation, employing various techniques), extremity adjusting, Activator technique (which uses a spring-loaded tool to deliver precise adjustments to the spine), Thompson Technique (which relies on a drop table and detailed procedural protocols), Gonstead (which emphasizes evaluating the spine along with specific adjustment that avoids rotational vectors), Cox/flexion-distraction (a gentle, low-force adjusting procedure which mixes chiropractic with osteopathic principles and utilizes specialized adjusting tables with movable parts), adjustive instrument, Sacro-Occipital Technique (which models the spine as a torsion bar), Nimmo Receptor-Tonus Technique, applied kinesiology (which emphasises "muscle testing" as a diagnostic tool), and cranial.[87] Chiropractic biophysics technique uses inverse functions of rotations during spinal manipulation.[88]Koren Specific Technique (KST) may use their hands, or they may use an electric device known as an "ArthroStim" for assessment and spinal manipulations.[89] Insurers in the US and UK that cover other chiropractic techniques exclude KST from coverage because they consider it to be "experimental and investigational".[89][90][91][92] Medicine-assisted manipulation, such as manipulation under anesthesia, involves sedation or local anesthetic and is done by a team that includes an anesthesiologist; a 2008 systematic review did not find enough evidence to make recommendations about its use for chronic low back pain.[93]
Many other procedures are used by chiropractors for treating the spine, other joints and tissues, and general health issues. The following procedures were received by more than one-third of patients of licensed US chiropractors in a 2003 survey: Diversified technique (full-spine manipulation; mentioned in previous paragraph), physical fitness/exercise promotion, corrective or therapeutic exercise, ergonomic/postural advice, self-care strategies, activities of daily living, changing risky/unhealthy behaviors, nutritional/dietary recommendations, relaxation/stress reduction recommendations, ice pack/cryotherapy, extremity adjusting (also mentioned in previous paragraph), trigger point therapy, and disease prevention/early screening advice.[84]
A 2010 study describing Belgian chiropractors and their patients found chiropractors in Belgium mostly focus on neuromusculoskeletal complaints in adult patients, with emphasis on the spine.[94] The diversified technique is the most often applied technique at 93%, followed by the Activator mechanical-assisted technique at 41%.[94] A 2009 study assessing chiropractic students giving or receiving spinal manipulations while attending a United States chiropractic college found Diversified, Gonstead, and upper cervical manipulations are frequently used methods.[95]
Reviews of research studies within the chiropractic community have been used to generate practice guidelines outlining standards that specify which chiropractic treatments are legitimate (i.e. supported by evidence) and conceivably reimbursable under managed care health payment systems.[81] Evidence-based guidelines are supported by one end of an ideological continuum among chiropractors; the other end employs antiscientific reasoning and makes unsubstantiated claims.[2][26][45][96][97] Chiropractic remains at a crossroads, and that in order to progress it would need to embrace science; the promotion by some for it to be a cure-all was both "misguided and irrational".[98] A 2007 survey of Alberta chiropractors found that they do not consistently apply research in practice, which may have resulted from a lack of research education and skills.[99] Specific guidelines concerning the treatment of nonspecific (i.e., unknown cause) low back pain are inconsistent between countries.[100]
Numerous controlled clinical studies of treatments used by chiropractors have been conducted, with varied results.[7] There is no conclusive evidence that chiropractic manipulative treatment is effective for the treatment of any medical condition, except perhaps for certain kinds of back pain.[7][9]
Generally, the research carried out into the effectiveness of chiropractic has been of poor quality.[101][102] Research published by chiropractors is distinctly biased: reviews of SM for back pain tended to find positive conclusions when authored by chiropractors, while reviews by mainstream authors did not.[7]
There is a wide range of ways to measure treatment outcomes.[103] Chiropractic care benefits from the placebo response,[104] but it is difficult to construct a trustworthy placebo for clinical trials of spinal manipulative therapy (SMT).[105] The efficacy of maintenance care in chiropractic is unknown.[106]
Available evidence covers the following conditions:
Low back pain. A 2013 Cochrane review found very low to moderate evidence that SMT was no more effective than inert interventions, sham SMT or as an adjunct therapy for acute low back pain.[107] The same review found that SMT appears to be no better than other recommended therapies.[107] A 2012 overview of systematic reviews found that collectively, SM failed to show it is an effective intervention for pain.[108] A 2011 Cochrane review found strong evidence that suggests there is no clinically meaningful difference between SMT and other treatments for reducing pain and improving function for chronic low back pain.[109] A 2010 Cochrane review found no difference between the effects of combined chiropractic treatments and other treatments for chronic or mixed duration low back pain.[110] A 2010 systematic review found that most studies suggest SMT achieves equivalent or superior improvement in pain and function when compared with other commonly used interventions for short, intermediate, and long-term follow-up.[111]
Radiculopathy. A 2013 systematic review and meta-analysis found a statistically significant improvement in overall recovery from sciatica following SM, when compared to usual care, and suggested that SM may be considered.[112] There is moderate quality evidence to support the use of SM for the treatment of acute lumbar radiculopathy[113] and acute lumbar disc herniation with associated radiculopathy.[114] There is low or very low evidence supporting SM for chronic lumbar spine-related extremity symptoms and cervical spine-related extremity symptoms of any duration and no evidence exists for the treatment of thoracic radiculopathy.[113]
Whiplash and other neck pain. There is no consensus on the effectiveness of manual therapies for neck pain.[115] A 2013 systematic review found that the data suggests that there are minimal short- and long-term treatment differences when comparing manipulation or mobilization of the cervical spine to physical therapy or exercise for neck pain improvement.[116] A 2013 systematic review found that although there is insufficient evidence that thoracic SM is more effective than other treatments, it is a suitable intervention to treat some patients with non-specific neck pain.[117] A 2011 systematic review found that thoracic SM may offer short-term improvement for the treatment of acute or subacute mechanical neck pain; although the body of literature is still weak.[118] A 2010 Cochrane review found low quality evidence that suggests cervical manipulation may offer better short-term pain relief than a control for neck pain, and moderate evidence that cervical manipulation and mobilization produced similar effects on pain, function and patient satisfaction.[119] A 2010 systematic review found low level evidence that suggests chiropractic care improves cervical range of motion and pain in the management of whiplash.[120]
Headache. There is conflicting evidence surrounding the use of chiropractic SMT for the treatment and prevention of migraine headaches.[121][122] A 2006 review found no rigorous evidence supporting SM or other manual therapies for tension headache.[123] A 2005 review found that the evidence was weak for effectiveness of chiropractic manipulation for tension headache, and that it was probably more effective for tension headache than for migraine.[124]
Extremity conditions. A 2011 systematic review and meta-analysis concluded that the addition of manual mobilizations to an exercise program for the treatment of knee osteoarthritis resulted in better pain relief than a supervised exercise program alone and suggested that manual therapists consider adding manual mobilization to optimize supervised active exercise programs.[125] There is silver level evidence that manual therapy is more effective than exercise for the treatment of hip osteoarthritis, however this evidence could be considered to be inconclusive.[126] There is a small amount of research into the efficacy of chiropractic treatment for upper limbs,[127] limited to low level evidence supporting chiropractic management of shoulder pain[128] and limited or fair evidence supporting chiropractic management of leg conditions.[129]
Other. A 2012 systematic review found insufficient low bias evidence to support the use of spinal manipulation as a therapy for the treatment of hypertension.[130] A 2011 systematic review found moderate evidence to support the use of manual therapy for cervicogenic dizziness.[131] There is very weak evidence for chiropractic care for adult scoliosis (curved or rotated spine)[132] and no scientific data for idiopathic adolescent scoliosis.[133] A 2007 systematic review found that few studies of chiropractic care for nonmusculoskeletal conditions are available, and they are typically not of high quality; it also found that the entire clinical encounter of chiropractic care (as opposed to just SM) provides benefit to patients with cervicogenic dizziness, and that the evidence from reviews is negative, or too weak to draw conclusions, for a wide variety of other nonmusculoskeletal conditions, including ADHD/learning disabilities, dizziness, high blood pressure, and vision conditions.[134] Other reviews have found no evidence of significant benefit for asthma,[135][136]baby colic,[137][138]bedwetting,[139]carpal tunnel syndrome,[140]fibromyalgia,[141]gastrointestinal disorders,[142] kinetic imbalance due to suboccipital strain (KISS) in infants,[137][143]menstrual cramps,[144]insomnia,[145]postmenopausal symptoms,[145] or pelvic and back pain during pregnancy.[146] As there is no evidence of effectiveness or safety for cervical manipulation for baby colic, it is not endorsed.[147]
The World Health Organization found chiropractic care in general is safe when employed skillfully and appropriately.[48] There is not sufficient data to establish the safety of chiropractic manipulations.[12] Manipulation is regarded as relatively safe but complications can arise, and it has known adverse effects, risks and contraindications.[48] Absolute contraindications to spinal manipulative therapy are conditions that should not be manipulated; these contraindications include rheumatoid arthritis and conditions known to result in unstable joints.[48] Relative contraindications are conditions where increased risk is acceptable in some situations and where low-force and soft-tissue techniques are treatments of choice; these contraindications include osteoporosis.[48] Although most contraindications apply only to manipulation of the affected region, some neurological signs indicate referral to emergency medical services; these include sudden and severe headache or neck pain unlike that previously experienced.[148] Indirect risks of chiropractic involve delayed or missed diagnoses through consulting a chiropractor.[7]
Spinal manipulation is associated with frequent, mild and temporary adverse effects,[13][148] including new or worsening pain or stiffness in the affected region.[149] They have been estimated to occur in 33% to 61% of patients, and frequently occur within an hour of treatment and disappear within 24 to 48 hours;[12] adverse reactions appear to be more common following manipulation than mobilization.[150] The most frequently stated adverse effects are mild headache, soreness, and briefly elevated pain fatigue.[151] Chiropractic is correlated with a very high incidence of minor adverse effects.[7] Rarely,[48] spinal manipulation, particularly on the upper spine, can also result in complications that can lead to permanent disability or death; these can occur in adults[13] and children.[152] Estimates vary widely for the incidence of these complications,[12] and the actual incidence is unknown, due to high levels of underreporting and to the difficulty of linking manipulation to adverse effects such as stroke, which is a particular concern.[13] Adverse effects are poorly reported in recent studies investigating chiropractic manipulations.[153] A 2016 systematic review concludes that the level of reporting is unsuitable and unacceptable.[154] Reports of serious adverse events have occurred, resulting from spinal manipulation therapy of the lumbopelvic region.[155] Estimates for serious adverse events vary from 5 strokes per 100,000 manipulations to 1.46 serious adverse events per 10 million manipulations and 2.68 deaths per 10 million manipulations, though it was determined that there was inadequate data to be conclusive.[12] Several case reports show temporal associations between interventions and potentially serious complications.[156] The published medical literature contains reports of 26 deaths since 1934 following chiropractic manipulations and many more seem to remain unpublished.[16]
Vertebrobasilar artery stroke (VAS) is statistically associated with chiropractic services in persons under 45 years of age, but it is similarly associated with general practitioner services, suggesting that these associations are likely explained by preexisting conditions.[156][157] Weak to moderately strong evidence supports causation (as opposed to statistical association) between cervical manipulative therapy (CMT) and VAS.[158] There is insufficient evidence to support a strong association or no association between cervical manipulation and stroke.[14] While the biomechanical evidence is not sufficient to support the statement that CMT causes cervical artery dissection (CD), clinical reports suggest that mechanical forces have a part in a substantial number of CDs and the majority of population controlled studies found an association between CMT and VAS in young people.[159] It is strongly recommended that practitioners consider the plausibility of CD as a symptom, and people can be informed of the association between CD and CMT before administering manipulation of the cervical spine.[159] There is controversy regarding the degree of risk of stroke from cervical manipulation.[14] Many chiropractors state that, the association between chiropractic therapy and vertebral arterial dissection is not proven.[16] However, it has been suggested that the causality between chiropractic cervical manipulation beyond the normal range of motion and vascular accidents is probable[16] or definite.[15] There is very low evidence supporting a small association between internal carotid artery dissection and chiropractic neck manipulation.[160] The incidence of internal carotid artery dissection following cervical spine manipulation is unknown.[161] The literature infrequently reports helpful data to better understand the association between cervical manipulative therapy, cervical artery dissection and stroke.[162] The limited evidence is inconclusive that chiropractic spinal manipulation therapy is not a cause of intracranial hypotension.[163] Cervical intradural disc herniation is very rare following spinal manipulation therapy.[164]
Chiropractors sometimes employ diagnostic imaging techniques such as X-rays and CT scans that rely on ionizing radiation.[165] Although there is no clear evidence to justify the practice, some chiropractors still X-ray a patient several times a year.[51] Practice guidelines aim to reduce unnecessary radiation exposure,[165] which increases cancer risk in proportion to the amount of radiation received.[166] Research suggests that radiology instruction given at chiropractic schools worldwide seem to be evidence-based.[50] Although, there seems to be a disparity between some schools and available evidence regarding the aspect of radiography for patients with acute low back pain without an indication of a serious disease, which may contribute to chiropractic overuse of radiography for low back pain.[50]
A 2012 systematic review concluded that no accurate assessment of risk-benefit exists for cervical manipulation.[14] A 2010 systematic review stated that there is no good evidence to assume that neck manipulation is an effective treatment for any medical condition and suggested a precautionary principle in healthcare for chiropractic intervention even if a causality with vertebral artery dissection after neck manipulation were merely a remote possibility.[16] The same review concluded that the risk of death from manipulations to the neck outweighs the benefits.[16] Chiropractors have criticized this conclusion, claiming that the author did not evaluate the potential benefits of spinal manipulation.[167]Edzard Ernst stated "This detail was not the subject of my review. I do, however, refer to such evaluations and should add that a report recently commissioned by the General Chiropractic Council did not support many of the outlandish claims made by many chiropractors across the world."[167] A 1999 review of 177 previously reported cases published between 1925 and 1997 in which injuries were attributed to manipulation of the cervical spine (MCS) concluded that "The literature does not demonstrate that the benefits of MCS outweigh the risks." The professions associated with each injury were assessed. Physical therapists (PT) were involved in less than 2% of all cases, with no deaths caused by PTs. Chiropractors were involved in a little more than 60% of all cases, including 32 deaths.[168]
A 2009 review evaluating maintenance chiropractic care found that spinal manipulation is associated with considerable harm and no compelling evidence exists to indicate that it adequately prevents symptoms or diseases, thus the risk-benefit is not evidently favorable.[11]
A 2012 systematic review suggested that the use of spine manipulation in clinical practice is a cost-effective treatment when used alone or in combination with other treatment approaches.[169] A 2011 systematic review found evidence supporting the cost-effectiveness of using spinal manipulation for the treatment of sub-acute or chronic low back pain; the results for acute low back pain were insufficient.[10]
A 2006 systematic cost-effectiveness review found that the reported cost-effectiveness of spinal manipulation in the United Kingdom compared favorably with other treatments for back pain, but that reports were based on data from clinical trials without placebo controls and that the specific cost-effectiveness of the treatment (as opposed to non-specific effects) remains uncertain.[170] A 2005 American systematic review of economic evaluations of conservative treatments for low back pain found that significant quality problems in available studies meant that definite conclusions could not be drawn about the most cost-effective intervention.[171] The cost-effectiveness of maintenance chiropractic care is unknown.[106][non-primary source needed]
Analysis of a clinical and cost utilization data from the years 2003 to 2005 by an integrative medicine independent physician association (IPA) which looked the chiropractic services utilization found that the clinical and cost utilization of chiropractic services based on 70,274 member-months over a 7-year period decreased patient costs associate with the following use of services by 60% for in-hospital admissions, 59% for hospital days, 62% for outpatient surgeries and procedures, and 85% for pharmaceutical costs when compared with conventional medicine (visit to a medical doctor primary care provider) IPA performance for the same health maintenance organization product in the same geography and time frame.[172]
Requirements vary between countries. In the U.S. chiropractors obtain a non-medical accredited diploma in the field of chiropractic.[173] Chiropractic education in the U.S. has been criticized for failing to meet generally accepted standards of evidence-based medicine.[174] The curriculum content of North American chiropractic and medical colleges with regard to basic and clinical sciences has little similarity, both in the kinds of subjects offered and in the time assigned to each subject.[175] Accredited chiropractic programs in the U.S. require that applicants have 90 semester hours of undergraduate education with a grade point average of at least 3.0 on a 4.0 scale. Many programs require at least three years of undergraduate education, and more are requiring a bachelor's degree.[176] Canada requires a minimum three years of undergraduate education for applicants, and at least 4200 instructional hours (or the equivalent) of full-time chiropractic education for matriculation through an accredited chiropractic program.[177] Graduates of the Canadian Memorial Chiropractic College (CMCC) are formally recognized to have at least 7–8 years of university level education.[178][179] The World Health Organization (WHO) guidelines suggest three major full-time educational paths culminating in either a DC, DCM, BSc, or MSc degree. Besides the full-time paths, they also suggest a conversion program for people with other health care education and limited training programs for regions where no legislation governs chiropractic.[48]
Upon graduation, there may be a requirement to pass national, state, or provincial board examinations before being licensed to practice in a particular jurisdiction.[180][181] Depending on the location, continuing education may be required to renew these licenses.[182][183] Specialty training is available through part-time postgraduate education programs such as chiropractic orthopedics and sports chiropractic, and through full-time residency programs such as radiology or orthopedics.[184]
In the U.S., chiropractic schools are accredited through the Council on Chiropractic Education (CCE) while the General Chiropractic Council (GCC) is the statutory governmental body responsible for the regulation of chiropractic in the UK.[185][186] The U.S. CCE requires a mixing curriculum, which means a straight-educated chiropractor may not be eligible for licensing in states requiring CCE accreditation.[76] CCEs in the U.S., Canada, Australia and Europe have joined to form CCE-International (CCE-I) as a model of accreditation standards with the goal of having credentials portable internationally.[187] Today, there are 18 accredited Doctor of Chiropractic programs in the U.S.,[188] 2 in Canada,[189] 6 in Australasia,[190] and 5 in Europe.[191] All but one of the chiropractic colleges in the U.S. are privately funded, but in several other countries they are in government-sponsored universities and colleges.[24] Of the two chiropractic colleges in Canada, one is publicly funded (UQTR) and one is privately funded (CMCC). In 2005, CMCC was granted the privilege of offering a professional health care degree under the Post-secondary Education Choice and Excellence Act, which sets the program within the hierarchy of education in Canada as comparable to that of other primary contact health care professions such as medicine, dentistry and optometry.[178][179]
Regulatory colleges and chiropractic boards in the U.S., Canada, Mexico, and Australia are responsible for protecting the public, standards of practice, disciplinary issues, quality assurance and maintenance of competency.[192][193] There are an estimated 49,000 chiropractors in the U.S. (2008),[194] 6,500 in Canada (2010),[195] 2,500 in Australia (2000),[28] and 1,500 in the UK (2000).[196]
Chiropractors often argue that this education is as good as or better than medical physicians', but most chiropractic training is confined to classrooms with much time spent learning theory, adjustment, and marketing.[76] The fourth year of chiropractic education persistently showed the highest stress levels.[197] Every student, irrespective of year, experienced different ranges of stress when studying.[197] The chiropractic leaders and colleges have had internal struggles.[198] Rather than cooperation, there has been infighting between different factions.[198] A number of actions were posturing due to the confidential nature of the chiropractic colleges in an attempt to enroll students.[198][clarification needed]
In 2024, Oregon Public Broadcasting reported on the high debt burden of students who pursued degrees in alternative medicine. Ten different chiropractic programs were ranked among the 47 US graduate programs with highest debt to earnings ratios.[199][200] Analyses by Quackwatch and the Sunlight Foundation found high rates of default on Health Education Assistance Loan (HEAL) student loans used for chiropractic programs.[201][202][203] Among health professionals who were listed as in default on HEAL loans in 2012, 53% were chiropractors.[203]
The chiropractic oath is a modern variation of the classical Hippocratic Oath historically taken by physicians and other healthcare professionals swearing to practice their professions ethically.[204] The American Chiropractic Association (ACA) has an ethical code "based upon the acknowledgement that the social contract dictates the profession's responsibilities to the patient, the public, and the profession; and upholds the fundamental principle that the paramount purpose of the chiropractic doctor's professional services shall be to benefit the patient."[205] The International Chiropractor's Association (ICA) also has a set of professional canons.[206]
A 2008 commentary proposed that the chiropractic profession actively regulate itself to combat abuse, fraud, and quackery, which are more prevalent in chiropractic than in other health care professions, violating the social contract between patients and physicians.[35] According to a 2015 Gallup poll of U.S. adults, the perception of chiropractors is generally favorable; two-thirds of American adults agree that chiropractors have their patient's best interest in mind and more than half also agree that most chiropractors are trustworthy. Less than 10% of US adults disagreed with the statement that chiropractors were trustworthy.[207][208]
The charity Sense about Science launched a campaign to draw attention to the BCA legal case against science writer Simon Singh.[209] In 2009, a number of organizations and public figures signed a statement entitled "The law has no place in scientific disputes".[210]
Chiropractors, especially in America, have a reputation for unnecessarily treating patients.[51] In many circumstances the focus seems to be put on economics instead of health care.[51] Sustained chiropractic care is promoted as a preventive tool, but unnecessary manipulation could possibly present a risk to patients.[7] Some chiropractors are concerned by the routine unjustified claims chiropractors have made.[7] A 2010 analysis of chiropractic websites found the majority of chiropractors and their associations made claims of effectiveness not supported by scientific evidence, while 28% of chiropractor websites advocate lower back pain care, which has some sound evidence.[211]
The US Office of the Inspector General (OIG) estimated that for calendar year 2013, 82% of payments to chiropractors under Medicare Part B, a total of $359 million, did not comply with Medicare requirements.[212] There have been at least 15 OIG reports about chiropractic billing irregularities since 1986.[212]
In 2009, a backlash to the libel suit filed by the British Chiropractic Association (BCA) against Simon Singh inspired the filing of formal complaints of false advertising against more than 500 individual chiropractors within one 24-hour period,[213][214] prompting the McTimoney Chiropractic Association to write to its members advising them to remove leaflets that make claims about whiplash and colic from their practice, to be wary of new patients and telephone inquiries, and telling their members: "If you have a website, take it down NOW" and "Finally, we strongly suggest you do NOT discuss this with others, especially patients."[213] An editorial in Nature suggested that the BCA may have been trying to suppress debate and that this use of English libel law was a burden on the right to freedom of expression, which is protected by the European Convention on Human Rights.[215] The libel case ended with the BCA withdrawing its suit in 2010.[216][217]
Chiropractic is established in the U.S., Canada, and Australia, and is present to a lesser extent in many other countries.[17] It is viewed as a marginal and non-clinically–proven attempt at complementary and alternative medicine, which has not integrated into mainstream medicine.[64]
In Australia, there are approximately 2488 chiropractors, or one chiropractor for every 7980 people.[218] Most private health insurance funds in Australia cover chiropractic care, and the federal government funds chiropractic care when the patient is referred by a medical practitioner.[219] In 2014, the chiropractic profession had a registered workforce of 4,684 practitioners in Australia represented by two major organizations – the Chiropractors' Association of Australia (CAA) and the Chiropractic and Osteopathic College of Australasia (COCA).[220] Annual expenditure on chiropractic care (alone or combined with osteopathy) in Australia is estimated to be between AUD$750–988 million with musculoskeletal complaints such as back and neck pain making up the bulk of consultations; and proportional expenditure is similar to that found in other countries.[220] While Medicare (the Australian publicly funded universal health care system) coverage of chiropractic services is limited to only those directed by a medical referral to assist chronic disease management, most private health insurers in Australia do provide partial reimbursement for a wider range of chiropractic services in addition to limited third party payments for workers compensation and motor vehicle accidents.[220]
Of the 2,005 chiropractors who participated in a 2015 survey, 62.4% were male and the average age was 42.1 (SD = 12.1) years.[220] Nearly all chiropractors (97.1%) had a bachelor's degree or higher, with the majority of chiropractor's highest professional qualification being a bachelor or double bachelor's degree (34.6%), followed by a master's degree (32.7%), Doctor of Chiropractic (28.9%) or PhD (0.9%).[220] Only a small number of chiropractor's highest professional qualification was a diploma (2.1%) or advanced diploma (0.8%).[220]
In Germany, chiropractic may be offered by medical doctors and alternative practitioners. Chiropractors qualified abroad must obtain a German non-medical practitioner license. Authorities have routinely required a comprehensive knowledge test for this, but in the recent past, some administrative courts have ruled that training abroad should be recognised.[221]
In Switzerland, only trained medical professionals are allowed to offer chiropractic.[222] Since 1995, chiropractors have been licensed to prescribe a limited set of pharmaceuticals, which were expanded in 2018.[223]
There are approximately 300 chiropractors in Switzerland.[224]
In the United Kingdom, there are over 2,000 chiropractors, representing one chiropractor per 29,206 people.[218] Chiropractic is available on the National Health Service in some areas, such as Cornwall, where the treatment is only available for neck or back pain.[225]
A 2010 study by questionnaire presented to UK chiropractors indicated only 45% of chiropractors disclosed to patients the serious risk associated with manipulation of the cervical spine and that 46% believed there was possibility patients would refuse treatment if the risks were correctly explained. However 80% acknowledged the ethical/moral responsibility to disclose risk to patients.[226]
In 2025, the American Chiropractic Association reported that 70,000 practitioners were active in the United States.[227] The percentage of the population that utilizes chiropractic care at any given time generally falls into a range from 6% to 12% in the U.S. and Canada,[228] with a global high of 20% in Alberta in 2006.[229] In 2008, chiropractors were reported to be the most common CAM providers for children and adolescents, these patients representing up to 14% of all visits to chiropractors.[230] A 2022 report found 11% of Americans visit a chiropractor.[231][better source needed][full citation needed]
There were around 50,330 chiropractors practicing in North America in 2000.[218] In 2008, this has increased by almost 20% to around 60,000 chiropractors.[7] In 2002–03, the majority of those who sought chiropractic did so for relief from back and neck pain and other neuromusculoskeletal complaints;[19] most do so specifically for low back pain.[19][228] The majority of U.S. chiropractors participate in some form of managed care.[8] Although the majority of U.S. chiropractors view themselves as specialists in neuromusculoskeletal conditions, many also consider chiropractic as a type of primary care.[8] In the majority of cases, the care that chiropractors and physicians provide divides the market, however for some, their care is complementary.[8]
In the U.S., chiropractors perform over 90% of all manipulative treatments.[232] Satisfaction rates are typically higher for chiropractic care compared to medical care, with a 1998 U.S. survey reporting 83% of respondents satisfied or very satisfied with their care; quality of communication seems to be a consistent predictor of patient satisfaction with chiropractors.[233]
Utilization of chiropractic care is sensitive to the costs incurred by the co-payment by the patient.[1] The use of chiropractic declined from 9.9% of U.S. adults in 1997 to 7.4% in 2002; this was the largest relative decrease among CAM professions, which overall had a stable use rate.[234] As of 2007 7% of the U.S. population is being reached by chiropractic.[235] They were the third largest medical profession in the US in 2002, following physicians and dentists.[236] Employment of U.S. chiropractors was expected to increase 14% between 2006 and 2016, faster than the average for all occupations.[194]
In the U.S., most states require insurers to cover chiropractic care, and most HMOs cover these services.[230]
Daniel David (D. D.) Palmer, founder of chiropractic
Chiropractic's origins lie in the folk medicine practice of bonesetting, in which untrained practitioners engaged in joint manipulation or resetting fractured bones.[7] Chiropractic was founded in 1895 by Daniel David (D. D.) Palmer in Davenport, Iowa. Palmer, a magnetic healer, hypothesized that manual manipulation of the spine could cure disease.[237] The first chiropractic patient of D. D. Palmer was Harvey Lillard, a worker in the building where Palmer's office was located.[57] He claimed that he had severely reduced hearing for 17 years, which started shortly following a "pop" in his spine.[57] A few days following his adjustment, Lillard claimed his hearing was almost completely restored.[57] Another of Palmer's patients, Samuel Weed, coined the term chiropractic, from Greekχειρο-chiro- 'hand' (itself from χείρcheir 'hand') and πρακτικόςpraktikos 'practical'.[238][239] Chiropractic is classified as a field of pseudomedicine.[240]
Chiropractic competed with its predecessor osteopathy, another medical system based on magnetic healing; both systems were founded by charismatic midwesterners in opposition to the conventional medicine of the day, and both postulated that manipulation improved health.[237] Although initially keeping chiropractic a family secret, in 1898 Palmer began teaching it to a few students at his new Palmer School of Chiropractic.[21] One student, his son Bartlett Joshua (B. J.) Palmer, became committed to promoting chiropractic, took over the Palmer School in 1906, and rapidly expanded its enrollment.[21]
Early chiropractors believed that all disease was caused by interruptions in the flow of innate intelligence, a vitalistic nervous energy or life force that represented God's presence in man; chiropractic leaders often invoked religious imagery and moral traditions.[21] D. D. Palmer said he "received chiropractic from the other world".[22] D. D. and B. J. both seriously considered declaring chiropractic a religion, which might have provided legal protection under the U.S. constitution, but decided against it partly to avoid confusion with Christian Science.[21][22] Early chiropractors also tapped into the Populist movement, emphasizing craft, hard work, competition, and advertisement, aligning themselves with the common man against intellectuals and trusts, among which they included the American Medical Association (AMA).[21]
Chiropractic has seen considerable controversy and criticism.[24][25] Although D. D. and B. J. were "straight" and disdained the use of instruments, some early chiropractors, whom B. J. scornfully called "mixers", advocated the use of instruments.[21] In 1910, B. J. changed course and endorsed X-rays as necessary for diagnosis; this resulted in a significant exodus from the Palmer School of the more conservative faculty and students.[21] The mixer camp grew until by 1924 B. J. estimated that only 3,000 of the United States' 25,000 chiropractors remained straight.[21] That year, B. J.'s invention and promotion of the neurocalometer, a temperature-sensing device, was highly controversial among B. J.'s fellow straights. By the 1930s, chiropractic was the largest alternative healing profession in the U.S.[21]
Chiropractors faced heavy opposition from organized medicine.[57] D. D. Palmer was jailed in 1907 for practicing medicine without a license.[241][full citation needed] Thousands of chiropractors were prosecuted for practicing medicine without a license, and D. D. and many other chiropractors were jailed.[57] To defend against medical statutes, B. J. argued that chiropractic was separate and distinct from medicine, asserting that chiropractors "analyzed" rather than "diagnosed", and "adjusted" subluxations rather than "treated" disease.[57] B. J. cofounded the Universal Chiropractors' Association (UCA) to provide legal services to arrested chiropractors.[57] Although the UCA won their first test case in Wisconsin in 1907, prosecutions instigated by state medical boards became increasingly common and in many cases were successful. In response, chiropractors conducted political campaigns to secure separate licensing statutes, eventually succeeding in all fifty states, from Kansas in 1913 through Louisiana in 1974.[57] The longstanding feud between chiropractors and medical doctors continued for decades.
The AMA labeled chiropractic an "unscientific cult" in 1966,[29] and until 1980 advised its members that it was unethical for medical doctors to associate with "unscientific practitioners".[242] This culminated in a landmark 1987 decision, Wilk v. AMA, in which the court found that the AMA had engaged in unreasonable restraint of trade and conspiracy, and which ended the AMA's de facto boycott of chiropractic.[8]
Serious research to test chiropractic theories did not begin until the 1970s, and is continuing to be hampered by antiscientific and pseudoscientific ideas that sustained the profession in its long battle with organized medicine.[57] By the mid-1990s there was a growing scholarly interest in chiropractic, which helped efforts to improve service quality and establish clinical guidelines that recommended manual therapies for acute low back pain.[57]
In recent decades chiropractic gained legitimacy and greater acceptance by medical physicians and health plans, and enjoyed a strong political base and sustained demand for services.[8] However, its future seemed uncertain: as the number of practitioners grew, evidence-based medicine insisted on treatments with demonstrated value, managed care restricted payment, and competition grew from massage therapists and other health professions.[8] The profession responded by marketing natural products and devices more aggressively, and by reaching deeper into alternative medicine and primary care.[8]
Some chiropractors oppose vaccination and water fluoridation, which are common public health practices.[35] Within the chiropractic community there are significant disagreements about vaccination, one of the most cost-effective public health interventions available.[243] Most chiropractic writings on vaccination focus on its negative aspects,[27] claiming that it is hazardous, ineffective, and unnecessary.[28] Some chiropractors have embraced vaccination, but a significant portion of the profession rejects it, as original chiropractic philosophy traces diseases to causes in the spine and states that vaccines interfere with healing.[28] The extent to which anti-vaccination views perpetuate the current chiropractic profession is uncertain.[27] The American Chiropractic Association and the International Chiropractors Association support individual exemptions to compulsory vaccination laws, and a 1995 survey of U.S. chiropractors found that about a third believed there was no scientific proof that immunization prevents disease.[28] The Canadian Chiropractic Association supports vaccination;[27] a survey in Alberta in 2002 found that 25% of chiropractors advised patients for, and 27% against, vaccinating themselves or their children.[244]
Early opposition to water fluoridation included chiropractors, some of whom continue to oppose it as being incompatible with chiropractic philosophy and an infringement of personal freedom. Other chiropractors have actively promoted fluoridation, and several chiropractic organizations have endorsed scientific principles of public health.[245] In addition to traditional chiropractic opposition to water fluoridation and vaccination, chiropractors' attempts to establish a positive reputation for their public health role are also compromised by their reputation for recommending repetitive lifelong chiropractic treatment.[35]
Throughout its history chiropractic has been the subject of internal and external controversy and criticism.[20][246] According to Daniel D. Palmer, the founder of chiropractic, subluxation is the sole cause of disease and manipulation is the cure for all diseases of the human race.[7][247] A 2003 profession-wide survey[58] found "most chiropractors (whether 'straights' or 'mixers') still hold views of innate intelligence and of the cause and cure of disease (not just back pain) consistent with those of the Palmers."[248] A critical evaluation stated "Chiropractic is rooted in mystical concepts. This led to an internal conflict within the chiropractic profession, which continues today."[7] Chiropractors, including D. D. Palmer, were jailed for practicing medicine without a license.[7] For most of its existence, chiropractic has battled with mainstream medicine, sustained by antiscientific and pseudoscientific ideas such as subluxation.[57] Collectively, systematic reviews have not demonstrated that spinal manipulation, the main treatment method employed by chiropractors, is effective for any medical condition, with the possible exception of treatment for back pain.[7] Chiropractic remains controversial, though to a lesser extent than in past years.[24]
^ abcd
Chapman-Smith DA, Cleveland CS III (2005). "International status, standards, and education of the chiropractic profession". In Haldeman S, Dagenais S, Budgell B, et al. (eds.). Principles and Practice of Chiropractic (3rd ed.). McGraw-Hill. pp. 111–34. ISBN978-0-07-137534-4.
Good R, Slezak P (2011). "Introductory Comments on Pseudoscience in Society and School". Science & Education. Springer. pp. 401–409. doi:10.1007/s11191-010-9331-2. The uncritical habits of mind that allow pseudosciences like subluxation chiropractic, astrology, intelligent design, and countless 'new age' medical cures to flourish are an important indication that science education needs to be changed.
^ abMootz RD, Shekelle PG (1997). "Content of practice". In Cherkin DC, Mootz RD (eds.). Chiropractic in the United States: Training, Practice, and Research. Rockville, MD: Agency for Health Care Policy and Research. pp. 67–91. OCLC39856366. AHCPR Pub No. 98-N002.
^ abPosadzki P, Ernst E (2011). "Spinal manipulation: an update of a systematic review of systematic reviews". The New Zealand Medical Journal. 124 (1340): 55–71. PMID21952385.
^Lazarus, David (June 30, 2017). Column: Chiropractic treatment, a $15-billion industry, has its roots in a ghost story.Archived July 19, 2020, at the Wayback Machine --- "Daniel David Palmer, the 'father' of chiropractic who performed the first chiropractic adjustment in 1895, was an avid spiritualist. He maintained that the notion and basic principles of chiropractic treatment were passed along to him during a seance by a long-dead doctor. 'The knowledge and philosophy given me by Dr. Jim Atkinson, an intelligent spiritual being ... appealed to my reason,' Palmer wrote in his memoir The Chiropractor, which was published in 1914 after his death in Los Angeles. Atkinson had died 50 years prior to Palmer's epiphany." Los Angeles Times. Retrieved: September 25, 2019.
^ abcJoseph C. Keating Jr.; Cleveland CS III; Menke M (2005). "Chiropractic history: a primer"(PDF). Association for the History of Chiropractic. Archived from the original(PDF) on 19 June 2013. Retrieved 2008-06-16. A significant and continuing barrier to scientific progress within chiropractic are the anti-scientific and pseudo-scientific ideas (Keating 1997b) which have sustained the profession throughout a century of intense struggle with political medicine. Chiropractors' tendency to assert the meaningfulness of various theories and methods as a counterpoint to allopathic charges of quackery has created a defensiveness which can make critical examination of chiropractic concepts difficult (Keating and Mootz 1989). One example of this conundrum is the continuing controversy about the presumptive target of DCs' adjustive interventions: subluxation (Gatterman 1995; Leach 1994).
^ abcdefKeating JC Jr (2005). "Philosophy in chiropractic". In Haldeman S, Dagenais S, Budgell B, et al. (eds.). Principles and Practice of Chiropractic (3rd ed.). McGraw-Hill. pp. 77–98. ISBN978-0-07-137534-4.
^Keating JC Jr (2005). "A brief history of the chiropractic profession". In Haldeman S, Dagenais S, Budgell B, et al. (eds.). Principles and Practice of Chiropractic (3rd ed.). McGraw-Hill. pp. 23–64. ISBN978-0-07-137534-4.
^ abcAmmendolia C, Taylor JA, Pennick V, Côté P, Hogg-Johnson S, Bombardier C (2008). "Adherence to radiography guidelines for low back pain: A survey of chiropractic schools worldwide". Journal of Manipulative and Physiological Therapeutics. 31 (6): 412–18. doi:10.1016/j.jmpt.2008.06.010. PMID18722195.
^ abcdSingh, S.; Ernst, E. (2008). "The truth about chiropractic therapy". Trick or Treatment: The Undeniable Facts about Alternative Medicine. W. W. Norton. pp. 145–90. ISBN978-0-393-06661-6.
^David Chapman-Smith (2000). "Principles and Goals of Chiropractic Care". The Chiropractic Profession: Its Education, Practice, Research and Future Directions. NCMIC Group. p. 160. ISBN978-1-892734-02-0.
^ abcMcDonald WP, Durkin KF, Pfefer M, et al. (2003). How Chiropractors Think and Practice: The Survey of North American Chiropractors. Ada, Ohio: Institute for Social Research, Ohio Northern University. ISBN978-0-9728055-5-1.[page needed]
^"Chirobase". Quackwatch. 7 May 2019. Archived from the original on 2020-06-10. Retrieved July 28, 2021.
^ abcVillanueva-Russell Y (June 2011). "Caught in the crosshairs: identity and cultural authority within chiropractic". Social Science & Medicine. 72 (11): 1826–37. doi:10.1016/j.socscimed.2011.03.038. PMID21531061.
^Redwood D, Hawk C, Cambron J, Vinjamury SP, Bedard J (2008). "Do chiropractors identify with complementary and alternative medicine? results of a survey". The Journal of Alternative and Complementary Medicine. 14 (4): 361–68. doi:10.1089/acm.2007.0766. PMID18435599.
^Bellamy, Jann J (2010). "Legislative alchemy: the US state chiropractic practice acts". Focus on Alternative and Complementary Therapies. 15 (3): 214–22. doi:10.1111/j.2042-7166.2010.01032.x.
^ abcMorrison P (2009). "Adjusting the role of chiropractors in the United States: why narrowing chiropractor scope of practice statutes will protect patients". Health Matrix. 19 (2): 493–537. PMID19715143.
^Wangler M, Zaugg B, Faigaux E (2010). "Medication Prescription: A Pilot Survey of Bernese Doctors of Chiropractic Practicing in Switzerland". Journal of Manipulative and Physiological Therapeutics. 33 (3): 231–237. doi:10.1016/j.jmpt.2010.01.013. PMID20350678.
^ abcVillanueva-Russell Y (2005). "Evidence-based medicine and its implications for the profession of chiropractic". Social Science & Medicine. 60 (3): 545–61. doi:10.1016/j.socscimed.2004.05.017. PMID15550303.
^ abcWinkler K, Hegetschweiler-Goertz C, Jackson PS, et al. (2003). "Spinal manipulation policy statement"(PDF). American Chiropractic Association. Archived from the original(PDF) on 2011-07-20. Retrieved 2008-05-24.
^Harrison DD, Janik TJ, Harrison GR, Troyanovich S, Harrison DE, Harrison SO (1996). "Chiropractic biophysics technique: a linear algebra approach to posture in chiropractic". Journal of Manipulative and Physiological Therapeutics. 19 (8): 525–35. PMID8902664.
^"Chiropractic Policy"(PDF). Oklahoma State University Health Plan. 1 April 2016. Archived from the original(PDF) on 5 January 2017. Retrieved 14 April 2016.
^Dagenais S, Mayer J, Wooley JR, Haldeman S (2008). "Evidence-informed management of chronic low back pain with medicine-assisted manipulation". The Spine Journal. 8 (1): 142–49. doi:10.1016/j.spinee.2007.09.010. PMID18164462.
^ abAilliet L, Rubinstein SM, de Vet HC (October 2010). "Characteristics of chiropractors and their patients in Belgium". Journal of Manipulative and Physiological Therapeutics. 33 (8): 618–25. doi:10.1016/j.jmpt.2010.08.011. PMID21036284.
^Ndetan HT, Rupert RL, Bae S, Singh KP (February 2009). "Prevalence of musculoskeletal injuries sustained by students while attending a chiropractic college". Journal of Manipulative and Physiological Therapeutics. 32 (2): 140–48. doi:10.1016/j.jmpt.2008.12.012. PMID19243726.
^Joseph C. Keating Jr. (1997). "Chiropractic: science and antiscience and pseudoscience side by side". Skeptical Inquirer. 21 (4): 37–43.
^Phillips RB (2005). "The evolution of vitalism and materialism and its impact on philosophy". In Haldeman S, Dagenais S, Budgell B, et al. (eds.). Principles and Practice of Chiropractic (3rd ed.). McGraw-Hill. pp. 65–76. ISBN978-0-07-137534-4.
^Suter E, Vanderheyden LC, Trojan LS, Verhoef MJ, Armitage GD (February 2007). "How important is research-based practice to chiropractors and massage therapists?". Journal of Manipulative and Physiological Therapeutics. 30 (2): 109–15. doi:10.1016/j.jmpt.2006.12.013. PMID17320731.
^Murphy AY, van Teijlingen ER, Gobbi MO (September 2006). "Inconsistent grading of evidence across countries: a review of low back pain guidelines". Journal of Manipulative and Physiological Therapeutics. 29 (7): 576–81, 581.e1–2. doi:10.1016/j.jmpt.2006.07.005. PMID16949948.
^Johnston BC, da Costa BR, Devereaux PJ, Akl EA, Busse JW (April 2008). "The use of expertise-based randomized controlled trials to assess spinal manipulation and acupuncture for low back pain: a systematic review". Spine. 33 (8): 914–18. doi:10.1097/BRS.0b013e31816b4be4. PMID18404113. S2CID28092478.
^Khorsan R, Coulter ID, Hawk C, Choate CG (June 2008). "Measures in chiropractic research: choosing patient-based outcome assessments". Journal of Manipulative and Physiological Therapeutics. 31 (5): 355–75. doi:10.1016/j.jmpt.2008.04.007. PMID18558278.
^Rubinstein SM, van Middelkoop M, Assendelft WJ, de Boer MR, van Tulder MW (June 2011). "Spinal manipulative therapy for chronic low-back pain: an update of a Cochrane review". Spine (Systematic review). 36 (13): E825–46. doi:10.1097/BRS.0b013e3182197fe1. hdl:1887/117578. PMID21593658. S2CID5061433.
^ abLeininger B, Bronfort G, Evans R, Reiter T (February 2011). "Spinal manipulation or mobilization for radiculopathy: a systematic review". Physical Medicine and Rehabilitation Clinics of North America. 22 (1): 105–25. doi:10.1016/j.pmr.2010.11.002. PMID21292148.
^Huisman PA, Speksnijder CM, de Wijer A (January 2013). "The effect of thoracic spine manipulation on pain and disability in patients with non-specific neck pain: a systematic review". Disability and Rehabilitation. 35 (20): 1677–85. doi:10.3109/09638288.2012.750689. PMID23339721. S2CID12159586.
^Gross A, Miller J, D'Sylva J, Burnie SJ, Goldsmith CH, Graham N, Haines T, Brønfort G, Hoving JL (August 2010). "Manipulation or mobilisation for neck pain: a Cochrane Review". Manual Therapy. 15 (4): 315–33. doi:10.1016/j.math.2010.04.002. PMID20510644.
^Shaw L, Descarreaux M, Bryans R, Duranleau M, Marcoux H, Potter B, Ruegg R, Watkin R, White E (2010). "A systematic review of chiropractic management of adults with Whiplash-Associated Disorders: recommendations for advancing evidence-based practice and research". Work. 35 (3): 369–94. doi:10.3233/WOR-2010-0996. PMID20364057.
^French HP, Brennan A, White B, Cusack T (April 2011). "Manual therapy for osteoarthritis of the hip or knee - a systematic review". Manual Therapy. 16 (2): 109–17. doi:10.1016/j.math.2010.10.011. PMID21146444.
^McHardy A, Hoskins W, Pollard H, Onley R, Windsham R (February 2008). "Chiropractic treatment of upper extremity conditions: a systematic review". Journal of Manipulative and Physiological Therapeutics. 31 (2): 146–59. doi:10.1016/j.jmpt.2007.12.004. PMID18328941.
^Pribicevic M, Pollard H, Bonello R, de Luca K (2010). "A systematic review of manipulative therapy for the treatment of shoulder pain". Journal of Manipulative and Physiological Therapeutics. 33 (9): 679–89. doi:10.1016/j.jmpt.2010.08.019. PMID21109059.
^Brantingham, James W.; Bonnefin, Debra; Perle, Stephen M.; Cassa, Tammy Kay; Globe, Gary; Pribicevic, Mario; Hicks, Marian; Korporaal, Charmaine (2012). "Manipulative Therapy for Lower Extremity Conditions: Update of a Literature Review". Journal of Manipulative and Physiological Therapeutics. 35 (2): 127–66. doi:10.1016/j.jmpt.2012.01.001. PMID22325966.
^Mangum K, Partna L, Vavrek D (2012). "Spinal manipulation for the treatment of hypertension: a systematic qualitative literature review". Journal of Manipulative and Physiological Therapeutics. 35 (3): 235–43. doi:10.1016/j.jmpt.2012.01.005. PMID22341795.
^Hawk C, Khorsan R, Lisi AJ, Ferrance RJ, Evans MW (June 2007). "Chiropractic care for nonmusculoskeletal conditions: a systematic review with implications for whole systems research". The Journal of Alternative and Complementary Medicine. 13 (5): 491–512. doi:10.1089/acm.2007.7088. PMID17604553.
Husereau D, Clifford T, Aker P, Leduc D, Mensinkai S (2003). Spinal Manipulation for Infantile Colic(PDF). Technology report no. 42. Ottawa: Canadian Coordinating Office for Health Technology Assessment. ISBN978-1-894978-11-8. Archived from the original(PDF) on 2008-12-17. Retrieved 2008-10-06.
^Huang, Tao; Shu, Xu; Huang, Yu Shan; Cheuk, Daniel KL; Huang, Tao (2011). "Complementary and miscellaneous interventions for nocturnal enuresis in children". Cochrane Database of Systematic Reviews (12): CD005230. doi:10.1002/14651858.CD005230.pub2. PMID22161390.
Sarac AJ, Gur A (2006). "Complementary and alternative medical therapies in fibromyalgia". Current Pharmaceutical Design. 12 (1): 47–57. doi:10.2174/138161206775193262. PMID16454724.
^Brand PL, Engelbert RH, Helders PJ, Offringa M (2005). "[Systematic review of the effects of therapy in infants with the KISS-syndrome (kinetic imbalance due to suboccipital strain)]". Nederlands Tijdschrift voor Geneeskunde (in Dutch). 149 (13): 703–07. PMID15819137.
^ abGoto, Viviane; Frange, Cristina; Andersen, Monica L.; Júnior, José M. S.; Tufik, Sergio; Hachul, Helena (May 2014). "Chiropractic intervention in the treatment of postmenopausal climacteric symptoms and insomnia: A review". Maturitas. 78 (1): 3–7. doi:10.1016/j.maturitas.2014.02.004. PMID24656717.
^Thiel HW, Bolton JE, Docherty S, Portlock JC (2007). "Safety of chiropractic manipulation of the cervical spine: a prospective national survey". Spine. 32 (21): 2375–78. doi:10.1097/BRS.0b013e3181557bb1. PMID17906581. S2CID42353750.
^Hurwitz EL, Morgenstern H, Vassilaki M, Chiang LM (July 2005). "Frequency and clinical predictors of adverse reactions to chiropractic care in the UCLA neck pain study". Spine. 30 (13): 1477–84. doi:10.1097/01.brs.0000167821.39373.c1. PMID15990659. S2CID45678522.
^Ernst E, Posadzki P (2012). "Reporting of adverse effects in randomised clinical trials of chiropractic manipulations: a systematic review". The New Zealand Medical Journal. 125 (1353): 87–140. PMID22522273.
^Gorrell LM, Engel RM, Brown B, Lystad RP (2016). "The reporting of adverse events following spinal manipulation in randomized clinical trials-a systematic review". The Spine Journal (Systematic Review). 16 (9): 1143–51. doi:10.1016/j.spinee.2016.05.018. PMID27241208.
^Chung CL, Côté P, Stern P, L'espérance G (2014). "The Association Between Cervical Spine Manipulation and Carotid Artery Dissection: A Systematic Review of the Literature". Journal of Manipulative and Physiological Therapeutics. 38 (9): 672–6. doi:10.1016/j.jmpt.2013.09.005. PMID24387889.
^Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation: Board on Radiation Effects Research" US National Research Council (2006). Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2. Washington, DC: The National Academies Press. doi:10.17226/11340. ISBN978-0-309-09156-5.
^Di Fabio, Richard P (January 1, 1999). "Manipulation of the Cervical Spine: Risks and Benefits". Physical Therapy. Retrieved November 1, 2021. Although the risk of injury associated with MCS appears to be small, this type of therapy has the potential to expose patients to vertebral artery damage that can be avoided with the use of mobilization (nonthrust passive movements). The literature does not demonstrate that the benefits of MCS outweigh the risks. Several recommendations for future studies and for the practice of MCS are discussed.
^Michaleff ZA, Lin CW, Maher CG, van Tulder MW (2012). "Spinal manipulation epidemiology: Systematic review of cost effectiveness studies". Journal of Electromyography and Kinesiology. 22 (5): 655–62. doi:10.1016/j.jelekin.2012.02.011. PMID22429823.
^van der Roer N, Goossens ME, Evers SM, van Tulder MW (2005). "What is the most cost-effective treatment for patients with low back pain? a systematic review". Best Practice & Research Clinical Rheumatology. 19 (4): 671–84. doi:10.1016/j.berh.2005.03.007. PMID15949783.
^Coulter I, Adams A, Coggan P, Wilkes M, Gonyea M (September 1998). "A comparative study of chiropractic and medical education". Alternative Therapies in Health and Medicine. 4 (5): 64–75. PMID9737032.
^"Becoming a chiropractor". Canadian Federation of Chiropractic Regulatory and Educational Accrediting Boards. Archived from the original on 2009-06-15. Retrieved 2009-06-05.
^Chapman-Smith D (2000). "Current status of the profession". The Chiropractic Profession: Its Education, Practice, Research and Future Directions. West Des Moines, IA: NCMIC. ISBN978-1-892734-02-0.
^ abcLeach, Matthew J. (2013-08-01). "Profile of the complementary and alternative medicine workforce across Australia, New Zealand, Canada, United States and United Kingdom". Complementary Therapies in Medicine. 21 (4): 364–378. doi:10.1016/j.ctim.2013.04.004. ISSN0965-2299. PMID23876568.
^Gaumer G (2006). "Factors associated with patient satisfaction with chiropractic care: survey and review of the literature". Journal of Manipulative and Physiological Therapeutics. 29 (6): 455–462. doi:10.1016/j.jmpt.2006.06.013. PMID16904491.
^Tindle HA, Davis RB, Phillips RS, Eisenberg DM (2005). "Trends in use of complementary and alternative medicine by US adults: 1997–2002". Alternative Therapies in Health and Medicine. 11 (1): 42–49. PMID15712765.
^Swanson ES (2015). "Pseudoscience". Science and Society: Understanding Scientific Methodology, Energy, Climate, and Sustainability. Springer. p. 65. ISBN978-3-319-21987-5.